The equianalgesic graph (or opioid) is a conversion chart that lists the equivalent analgesic dose (a drug used for pain relief). The equianalgesic chart is used for calculating the equivalent dose (dose that will offer the same amount of analgesia) between different analgesics. This general type table is also available for NSAIDs, benzodiazepines, depressants, stimulants, anticholinergics and others.
Video Equianalgesic
Format
Equianalgesic tables are available in various formats, such as pocket-sized cards for easy reference. The frequently viewed format has the name of the drug in the left column, the administrative route in the middle column and the note in the right column.
Maps Equianalgesic
Destination
There are several reasons to divert patients to different pain medications. This includes practical considerations such as lower costs or unavailability of drugs in the pharmacies favored by patients, or medical reasons such as lack of current drug effectiveness or to minimize side effects. Some patients request to switch to different narcotics due to the stigma associated with certain drugs (eg patients who reject methadone due to their association with opioid addiction treatment). Equianalgesic charts are also used when calculating equal doses of the same drug, but with different route of administration.
Precautions
The equianalgesic chart can be a useful tool, but users should be careful to correct all relevant variables such as route administration, cross tolerance, half-life and drug bioavailability. For example, narcotic levorphanol is 4-8 times stronger than morphine, but also has a longer half-life. Simply switching patients from 40 mg of morphine to 10 mg levorphanol would be dangerous because of the accumulation of dosage, and therefore the frequency of administration should also be taken into account.
There are other concerns about the equianalgesic chart. Many graphs obtained their data from research conducted on opioid-naÃÆ'¯ve patients. Patients with chronic pain (not acute) may respond to analgesia differently. Repeated drug administration also differs from a single dose, since many drugs have active metabolites that can accumulate in the body. Patient variables such as gender, age, and organ function can also affect drug effects on the system. These variables are rarely included in the equianalgesic chart.
Opioid equivalence table
Opioids are a class of compounds that cause analgesic effects (kill pain) in humans and animals by binding to Âμ-opioid receptors in the central nervous system. The following table lists opioid and non-opioid analgesic drugs and their relative potential. Values ​​for potential represent opioids taken orally unless other administrative routes are provided. Thus, their bioavailability is different, and they may be stronger when taken intravenously. Methadone differs from most opioids considering its potential may vary depending on how long it takes. The acute use, 1-3 days, yields a potency of about 1.5 to 100% stronger than morphine and chronic use (7 days) yields a potential of about 2.5-5 ÃÆ'â € "morphine because methadone is stored in fatty tissue, thus giving more high serum levels with longer use. Similarly, the tramadol effect increased after successive dosing due to active metabolite accumulation and increased oral bioavailability in chronic use; this effect becomes less significant with longer use when tolerance develops.
See also
- Oripavine - for more about the comparative power of oripavine derivatives
Note
References
External links
- Equianalgesic Chart
- American Pain Society Guidelines
- Clinical Practice Guidelines for Opioid Therapy Management for Chronic Pain
- Online equianalgesia opioid calculators Electronic calculators that include logic for bidirectional and dose-dependent conversions
- Equianalgesic table Opioid: are they all equally dangerous?
Source of the article : Wikipedia
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